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Pgr Gene Detail
Summary
  • Symbol
    Pgr
  • Name
    progesterone receptor
  • Synonyms
    9930019P03Rik, ENSMUSG00000074510, NR3C3, PR, PR-A, PR-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:97567
    NCBI Gene: 18667
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:8899834-8968612 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2212 from dbSNP Build 142
  • Strain Annotations
    20
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97567
 protein coding gene Chr9:8890017-8968612 (+)
129S1/SvImJ ENSMUSG00200022561
 protein coding gene Chr9:5756348-5825161 (+)
A/J ENSMUSG00195018269
 protein coding gene Chr9:5668357-5737144 (+)
AKR/J ENSMUSG00220018653
 protein coding gene Chr9:5637251-5705772 (+)
AKR/J ENSMUSG00220018659
 protein coding gene Chr9:5704582-5716353 (+)
BALB/cJ ENSMUSG00180011363
 protein coding gene Chr9:5800764-5869550 (+)
C3H/HeJ ENSMUSG00175024015
 protein coding gene Chr9:5725017-5793788 (+)
C57BL/6NJ ENSMUSG00215006524
 protein coding gene Chr9:5738915-5807711 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031768
 protein coding gene Chr9:5028358-5095638 (+)
CAST/EiJ ENSTCUG00005007274
 protein coding gene Chr9:5752756-5824811 (+)
CBA/J ENSMUSG00210010563
 protein coding gene Chr9:5785986-5854775 (+)
DBA/2J ENSMUSG00185004963
 protein coding gene Chr9:5868723-5937512 (+)
FVB/NJ ENSMUSG00205007165
 protein coding gene Chr9:5841244-5910034 (+)
JF1/MsJ ENSUMUG00000006572
 protein coding gene Chr9:5853998-5925473 (+)
LP/J ENSMUSG00230003451
 protein coding gene Chr9:6297694-6366492 (+)
NOD/ShiLtJ ENSMUSG00190022230
 protein coding gene Chr9:5776935-5845720 (+)
NZO/HlLtJ ENSMUSG00225015925
 protein coding gene Chr9:6208295-6277079 (+)
PWK/PhJ ENSLUMG00010006380
 protein coding gene Chr9:5835046-5906285 (+)
SPRET/EiJ ENSMSPG00010005434
 protein coding gene Chr9:5889283-5960573 (+)
WSB/EiJ ENSIUOG00005007482
 protein coding gene Chr9:5541645-5610467 (+)



Homology
more
  • Human Ortholog
    PGR, progesterone receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PGR, progesterone receptor
  • Synonyms
    NR3C3, PR
  • Links
    NCBI Gene ID: 5241
    UniProt: P06401

  • Chr Location
    11q22.1; chr11:101029624-101129813 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human PGR associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    56 phenotypes from 10 alleles in 10 genetic backgrounds
    83 phenotypes from multigenic genotypes
    3 images
    395 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null female mice are sterile and exhibit ovulatory defects, uterine hyperplasia, and impaired mammary development. Females lacking only isoform A are infertile but show normal mammary development, while females lacking only isoform B are fertile but present with mammary developmental defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    88
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    118
  • cDNA Data
    18
  • Literature Summary
    55
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031870 Ensembl Gene Model | MGI Sequence Detail 68779 C57BL/6J ±  kb
    transcript ENSMUST00000189181 Ensembl | MGI Sequence Detail 6889 Not Applicable  
    polypeptide ENSMUSP00000140124 Ensembl | MGI Sequence Detail 926 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 5
      cDNA 18
      Primer pair 6
      Other 1
      Antibodies 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13282, MGI:2143361, MGI:2444097, MGI:3642750
    References
    more
    • Summaries
      All 523
      Developmental Gene Expression 55
      Diseases 6
      Gene Ontology 20
      Phenotypes 395
    • Earliest
      J:12501 Naylor SL, et al., The progesterone receptor gene is on mouse Chromosome 9. Cytogenet Cell Genet. 1989;51:1051 (Abstr.)
    • Latest
      J:390162 Suto N, et al., Neural circuits for valence updating in social memory. Science. 2026 Jul 9;393(6807):eadx8231
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory